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KMID : 0603219950020020104
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Korean Journal of Rhinology
1995 Volume.2 No. 2 p.104 ~ p.109
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The Effect of Leukotriene D4 on the Patency of Nasal passage in Guinea Pigs
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Abstract
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Acoustic reflection have been used in adult human to determine nasal cavity dimension in terms of cross-sectional area as a function of the distance from nostril. In order to measure nasal cavity dimensions in guinea pigs, we modified equipment
for
sue
in human by decreasing sound tube dimension, increasing sampling frequency, and applying a special nosepiece.
The percent change of volume(VOL) from the nostril to 2cm into the nasal cavity showed significant reduction at 30 minutes and 6 hours after instillation of LTD4 in guinea pigs. However the guinea pig instilled saline did not show any change in
VOL.
This results indicated that the leukotriene was an potent mediator to induce nasal obstruction of late reaction in guinea pig.
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